Sex linked recessive disorder
X and Y are sex chromosomes. Dominant inheritance occurs when an abnormal gene from one parent causes disease, even though the matching gene from the other parent is normal. The abnormal gene dominates. But in recessive inheritance, both matching genes must be abnormal to cause disease.
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Sex-linked recessive: MedlinePlus Medical Encyclopedia
Every cell in the human body has 23 pairs of chromosomes. One of these pairs is made up of 2 sex chromosomes. These are called X and Y chromosomes. One of these is inherited from the mother and the other from the father. Females have 2 X chromosomes, while males have 1 X and 1 Y chromosome. Chromosomes are made of genes.
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X-linked recessive genetic defects - how girls are affected
X-linked recessive inheritance is a mode of inheritance in which a mutation in a gene on the X chromosome causes the phenotype to be always expressed in males who are necessarily homozygous for the gene mutation because they have one X and one Y chromosome and in females who are homozygous for the gene mutation, see zygosity. Females with one copy of the mutated gene are carriers. X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes while males have one X and one Y chromosome.
There are several X-linked or sex-linked recessive genetic disorders, hemophilia, muscular dystrophy which are inherited through a genetic defect on an X chromosome. A female has 2 X chromosomes, one she inherited from her mother and one she got from her father. A male has an X chromosome from his mother and a Y chromosome from his father. Females may get the defective gene either from her mother's defective X, or, if her father has the disorder, from her father. In either case, the girl will be a carrier and will probably pass the defect to her offspring.
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